Solutions for COVID-19 vaccine safety and immunogenicity evaluation
Background
Applications
Product list
Background
With the efforts of the scientist around the world, up until now, there are now several COVID-19 vaccines that are in use.
In the development of a COVID-19 vaccine, safety and immunogenicity evaluation are indispensable and well-established assays are required for fast and convenient assessment of the vaccine candidates.
Based on advanced technology platform in recombinant protein production, ACROBiosystems has developed a series of critical reagents for COVID-19 vaccine development and evaluation, including ELISA kits, recombinant proteins and antibodies. These featured products are suitable for IgG/M antibody titer detection, neutralizing antibody titer detection and antigen titer detection to accelerate the vaccine development.
Product list
Proteins
| Molecule | Cat. No. | Product Description |
|---|---|---|
| ACE2 protein | AC2-H52H8 | Human ACE2 / ACEH Protein, His Tag (MALS verified) |
| AC2-H82E6 | Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified) | |
| AC2-H5257 | Human ACE2 / ACEH Protein, Fc Tag (MALS verified) | |
| AC2-H82F9 | Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™ | |
| S trimer protein | SPN-C52H9 | SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS & NS-EM verified) |
| SPN-C82E9 | Biotinylated SARS-CoV-2 S protein, His,Avitag™, Super stable trimer (MALS verified) | |
| SPN-C52H3 | SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified) | |
| SPN-C82E3 | Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag™, Super stable trimer (MALS verified) | |
| S protein RBD | SPD-C52H3 | SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified) |
| SPD-C82E9 | Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified) | |
| SPD-C5259 | SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc Tag(MALS verified) | |
| SPD-C82Aa | Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG1 Fc,Avitag™(MALS verified) | |
| S1 protein | S1N-C52H4 | SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified) |
| S1N-C82E8 | Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified) | |
| S1N-C5256 | SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag | |
| S1N-C82E3 | Biotinylated SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™ | |
| S1 protein NTD | S1D-C52H6 | SARS-CoV-2 (COVID-19) S1 protein NTD, His Tag |
| S1 protein CTD | S1D-C52H3 | SARS-CoV-2 (COVID-19) S1 protein CTD, His Tag (MALS-verified) |
| S2 protein | S2N-C52H5 | SARS-CoV-2 (COVID-19) S2 protein, His Tag |
| Nucleocapsid protein | NUN-C5227 | SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag |
| NUN-C82E8 | Biotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™ |
Kits
| Category | Species | Cat.No. | Product Description | sample |
|---|---|---|---|---|
| Neutralizing antibody titer assay kit | (D614G) | TAS-K022 | Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay Kit (CE certified) | Human Serum |
| RAS-N022 | Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay Kit | Human Serum | ||
| TAS-N035 | Anti-SARS-CoV-2 Neutralizing Antibody Detection Kit (Spike RBD) (CE certified) | Human Serum | ||
Alpha | B.1.1.7 (U.K.) | RAS-N028 | Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-N036 | Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Serologic Assay Kit (Spike Trimer) | Human Serum | ||
Beta | B.1.351 (South Africa) | RAS-N031 | Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-N037 | Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Serologic Assay Kit (Spike Trimer) | Human Serum | ||
Gamma | P.1 (Brazil) | RAS-N034 | Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-N038 | Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Serologic Assay Kit (Spike Trimer) | Human Serum | ||
| Antibody titer assay kit | (D614G) | TAS-K002 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD) (CE certified) | Human Serum |
| TAS-K024 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD) (CE certified) | Human Serum | ||
| TAS-K007 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike Protein) (CE certified) | Human Serum | ||
| TAS-K025 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer) (CE certified) | Human Serum | ||
| RAS-T001 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1) | Human Serum | ||
| RAS-T008 | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein) | Human Serum | ||
| RAS-T009 | Anti-SARS-CoV-2 Total Antibody Titer Serologic Assay kit (Spike RBD) | Human Serum | ||
| RAS-T012 | Anti-SARS-CoV-2 Antibody IgM Titer Serologic Assay Kit (Spike S1) | Human Serum | ||
| RAS-T013 | Anti-SARS-CoV-2 Antibody IgM Titer Serologic Assay Kit (Spike RBD) | Human Serum | ||
| RAS-T018 | Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit | Mouse Serum | ||
| RAS-T023 | Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | Mouse Serum | ||
| RAS-T019 | Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit | Monkey Serum | ||
Alpha | B.1.1.7 (U.K.) | RAS-T026 | Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-T027 | Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | Human Serum | ||
Beta | B.1.351 (South Africa) | RAS-T029 | Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-T030 | Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | Human Serum | ||
Gamma | P.1 (Brazil) | RAS-T032 | Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-T033 | Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | Human Serum | ||
| Antibody isotype assay kit | (D614G) | RAS-T014 | Anti-SARS-CoV-2 Antibody IgG1 Titer Serologic Assay kit | Human Serum |
| RAS-T015 | Anti-SARS-CoV-2 Antibody IgG2 Titer Serologic Assay kit | Human Serum | ||
| RAS-T016 | Anti-SARS-CoV-2 Antibody IgG3 Titer Serologic Assay kit | Human Serum | ||
| RAS-T017 | Anti-SARS-CoV-2 Antibody IgG4 Titer Serologic Assay kit | Human Serum |
Antibodies
| Molecule | Cat. No. | Product Description |
|---|---|---|
| S protein RBD | SPD-M180 | Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody (AM180) |
| SPD-M128 | Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128) | |
| S1 protein | S1N-M122 | Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) |
| S1N-M130 | Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM130) |
Antibody isotype assay products
| Category | Cat. No. | Product Description |
|---|---|---|
| Antibody isotype | SAD-S35 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1（AS35） |
| SPD-S66 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG2（AS35） | |
| SPD-S67 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG3（AS35） | |
| SPD-S68 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG4（AS35） | |
| HRP- secondary antibody | IG1-S71 | Mouse Anti-Human IgG1 secondary antibody, Mouse IgG1, HRP |
| IG2-S72 | Mouse Anti-Human IgG2 secondary antibody, Mouse IgG1, HRP | |
| IG3-S73 | Mouse Anti-Human IgG3 secondary antibody, Mouse IgG1, HRP | |
| IG4-S74 | Mouse Anti-Human IgG4 secondary antibody, Mouse IgG1, HRP |
Reference：
[1] Mulligan et al., (2020). Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report. medRxiv, doi: https://doi.org/10.1101/2020.06.30.20142570 )